Angiogenesis and Hypoxia: Making More Blood Vessels


Getting back to angiogenesis (creation of new blood vessels), which accounts for the main mass of the penile tissues (when not engorged with blood), I have stumbled upon the subject of hypoxia inducing factors (HIF), which basically removes oxygen from the cells where it is injected. When the cell is hypoxic (lack of oxygen), it releases a signal to nearby blood vessels to sprout new pathways to the oxygen-deprived cells. This signal is called vascular endothelial growth factor, or VEGF for short. The new blood vessels connect to the existing vascular network, provide oxygen via the red blood cells, and the signalling stops.

Hypoxia inducing factors have been successfully injected into patients with kidney disease, the result being a revascularization of the damaged parts of the organ. While there are several HIFs in existance, there are also different types. One in particular is cobalt chloride, which is a very common laboratory chemical. It is blue when dry, and pink when hydrated, making it a useful indicator of the presence of humidity in containers that need to stay dry.

Cobalt is the molecule at the heart of vitamin B12, cyanocobalamine. It is an essential component for the creation of new blood cells. But there is doubt that the vitamin B12 could cause angiogenesis where injected, since it is attached to many other molecules that make it very large in size. Cobalt chloride in solution is ionic, with free cobalt ions without attachment atoms. I speculate that these cobalt ions displace oxygen in cells, which causes them to release VEGF to provide oxygen from nearby unaffected blood vessels.

If the creation of new blood vessels occur, then the potential for penis enlargement exists with the use of cobalt as a HIF that leads to angiogenesis.

The logical step after would be to create a larger number of blood cells to populate the new vessels. Of course, more research is required, but the future is full of promise.

Thanks for reading!

Ronielle out

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Ronielle

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