Receptor Site Population and Effective Vasodilation
The continual saturation of pge-1 receptor sites may lead to increasing the number of penile cells, which in turn increases the total number of pge-1 receptor sites. This may explain why Pge-1 dose increases over time, to continually saturate the ever increasing number of blood vessel in the growing penis.
Prostaglandin E1 receptors are located in the smooth muscles lining the walls of blood vessels. PGE-1 attaching to its receptors causes the smooth muscles to relax, and in doing so, more blood is drawn into the penis. No sexual stimulation is needed for this type of erection like oral erectile dysfunction medications do. With blood vessel walls relaxed, blood pressure in the corpus cavernosum increases; prolonged erections and frequent injections leads me to speculate that angiogenesis (blood vessel growth) is provoked. More study on the physiological process of angiogenesis is underway. Those following me on this research should keyword search 'angiogenesis penis'. Google has produced some very interesting links to studies associated with erectile dysfunction as well.
In any case, since my research has lead me to the fact that the penis is a vascular organ, and is mainly made of smooth muscle cells, (by transitive property) angiogenesis occurs with penis enlargement. This may seem obvious now, but I actually did not link penis enlargement with the term angiogenesis. Going deeper is to study exactly what triggers blood vessel growth at the capillary level, and preliminary research suggests that it has mainly to do with a vascular endothelial growth factor (VEGF).
Getting back to the subject, angiogenesis creates more blood vessels (by definition), and more blood vessels mean more smooth muscle cells (SMC), which in turn means each new SMC has PGE-1 receptors. The total amount of PGE-1 receptors in the penis increases, which indicates that, to maintain the same intensity of erection as before the new growth, more PGE-1 must be injected to ensure adequate erectile response. Basically, drug tolerance is due to insufficient amounts of PGE-1 to activate the growing number of receptor sites in the penis, resulting in a continual increased dose of alprostadil (PGE-1) over time. The drug is not getting less effective, it just becomes not enough due to penile growth over time.
Phew! I don't usually write so technical, but I think I am watching too much Big Bang Theory. As soon as I get a better grasp on the subject, I should come up with a better way of explaining it.
I never knew I would be getting this deep into research, but my obsession compels me to understand as much as I can. Passion for cock is an understatement at this point!
Thanks for reading, and good luck in your own PE efforts!
Ronielle